Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP14 | Q460N5 | 4/20 | 0.38 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 2/20 | 0.34 |
| ▸ | F3 | P13726 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | MDH2 | P40926 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29270705 | 0.89 | PARP14 (0.39) | PARP14TP53MAPTSMN1; SMN2THRB | |
| SCHEMBL29270728 | 0.82 | PARP14 (0.40) | PARP14 | |
| SCHEMBL29270690 | 0.78 | ALDH1A1 (0.41) | XIAPTP53MAPTSMN1; SMN2LMNA | |
| SCHEMBL29270819 | 0.78 | NOTUM (0.37) | TP53MAPTSMN1; SMN2LMNA | |
| SCHEMBL29270847 | 0.77 | TP53 (0.47) | TP53MAPTSMN1; SMN2LMNA | |
| SCHEMBL29270781 | 0.76 | TP53 (0.37) | TP53MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL29270852 | 0.75 | PTGDR2 (0.37) | TP53MAPTSMN1; SMN2THRBLMNA | |
| SCHEMBL29270810 | 0.74 | TP53 (0.35) | TP53MAPTSMN1; SMN2LMNAPOLB | |
| SCHEMBL29270726 | 0.73 | TP53 (0.37) | TP53MAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL29270744 | 0.72 | TP53 (0.34) | TP53MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | disclosed |