Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24154698 | 0.76 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA7CYP2A6CHRNB4 | |
| Hydrochloric Acid SCHEMBL28973743 | 0.75 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA7CYP2A6CHRNB4 | |
| SCHEMBL6032944 | 0.70 | CHRNB2 (0.45) | CHRNB2CHRNA4CHRNA7CYP2A6CHRNA3 | |
| SCHEMBL1741490 | 0.67 | SLC6A2 (0.53) | CHRNB2CHRNA4CHRNA7CYP2A6SLC6A2 | |
| SCHEMBL6169570 | 0.67 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA7CYP2A6 | |
| SCHEMBL1403947 | 0.65 | CHRNB2 (0.39) | CHRNB2CHRNA4BPTF | |
| SCHEMBL29770692 | 0.65 | CHRNB2 (0.39) | CHRNB2CHRNA4BPTF | |
| SCHEMBL8199299 | 0.64 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNA7CYP2A6 | |
| SCHEMBL24154223 | 0.63 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNA7CYP2A6CHRNB4 | |
| SCHEMBL11955257 | 0.63 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA7CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231656-A1 | FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS | Amgen Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009085185-A1 | FUSED PYRIDINE, PYRIMIDINE AND TRIAZINE COMPOUNDS AS CELL CYCLE INHIBITORS | AMGEN INC. (US) | 2009-07-09 | — | — | WO | disclosed |