SCHEMBL1741490

SCHEMBL1741490

Clc1ccc(C2CC=CCN2)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 9/20 0.53
SLC6A3 Q01959 9/20 0.53
CHRNA7 P36544 3/20 0.51
CHRNB2 P17787 2/20 0.51
CHRNA4 P43681 2/20 0.51
CYP2A6 P11509 1/20 0.51
SLC6A4 P31645 6/20 0.38
CYP2D6 P10635 5/20 0.38
KCNH2 Q12809 5/20 0.38
HTR3A P46098 1/20 0.36
PRCP P42785 1/20 0.35
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
LMNA P02545 1/20 0.33
HPGD P15428 1/20 0.33
KMT2A Q03164 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1889514 0.79 CHRNB2 (0.65) SLC6A2SLC6A3CHRNA7CHRNB2CHRNA4
SCHEMBL24154698 0.78 CHRNB2 (0.54) CHRNA7CHRNB2CHRNA4CYP2A6MEN1
Hydrochloric Acid SCHEMBL28973743 0.77 CHRNB2 (0.53) CHRNA7CHRNB2CHRNA4CYP2A6MEN1
SCHEMBL1069753 0.73 SLC6A3 (0.48) SLC6A2SLC6A3CHRNA7CYP2A6SLC6A4
SCHEMBL24154223 0.72 CHRNB2 (0.47) SLC6A2SLC6A3CHRNA7CHRNB2CHRNA4
SCHEMBL8577722 0.72 CHRNB2 (0.44) SLC6A2SLC6A3CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL28973699 0.71 CHRNB2 (0.46) SLC6A2SLC6A3CHRNA7CHRNB2CHRNA4
SCHEMBL170771 0.70 HTR3A (0.50) SLC6A2SLC6A3CHRNA7CHRNB2CHRNA4
SCHEMBL9630207 0.70 CHRNB2 (0.42) CHRNA7CHRNB2CHRNA4CYP2A6ALDH1A1
SCHEMBL3966012 0.69 SLC6A2 (0.42) SLC6A2SLC6A3CHRNA7CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2389379-A1 Poly (ADP-Ribose) Polymerase (PARP) Inhibitors Takeda Pharmaceutical Company Limited (JP) 2011-11-30 EP disclosed
WO-2010085570-A1 Poly (ADP-Ribose) Polymerase (PARP) Inhibitors TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-07-29 WO disclosed
EP-1751138-A1 INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS EGIS Gyógyszergyár Nyrt (HU) 2007-02-14 EP disclosed
WO-2005108390-A1 INDOL-2-ONE DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS DISORDERS, GASTROINTESTINAL DISORDERS AND CARDIOVASCULAR DISORDERS EGIS GYÓGYSZERGYÁR NYRT. (HU) 2005-11-17 WO disclosed