Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 12/20 | 0.65 |
| ▸ | HTR2C | P28335 | 11/20 | 0.65 |
| ▸ | HTR2B | P41595 | 8/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7840850 | 0.88 | HTR2C (0.52) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL2931184 | 0.84 | HTR2C (0.63) | HTR2AHTR2CHTR2BGPR84PTGS2 | |
| SCHEMBL26965630 | 0.81 | HTR2C (0.68) | HTR2AHTR2CHTR2BGPR84PTGS2 | |
| SCHEMBL26965705 | 0.79 | HTR2A (0.65) | HTR2AHTR2CHTR2BGPR84 | |
| SCHEMBL29511842 | 0.79 | HTR2C (1.00) | HTR2AHTR2CHTR2B | |
| SCHEMBL26965698 | 0.79 | HTR2C (0.65) | HTR2AHTR2CHTR2BGPR84PTGS2 | |
| SCHEMBL12558828 | 0.79 | HTR2C (1.00) | HTR2AHTR2CHTR2B | |
| Iodide SCHEMBL30823262 | 0.78 | CHRM2 (0.46) | HTR2AHTR2CHTR2BCHRM2CHRM1 | |
| SCHEMBL20119869 | 0.78 | HTR2C (0.63) | HTR2AHTR2CHTR2B | |
| SCHEMBL27542807 | 0.78 | HTR2C (0.67) | HTR2AHTR2CHTR2BGPR84PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528650-B2 | Mixture containing coupler | L'OREAL S.A. (FR) | 2003-03-04 | — | — | US | claimed |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2003-01-30 | — | — | US | claimed |
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2002-03-21 | — | — | US | claimed |
| US-6306181-B1 | FOR DYEING HUMAN HAIR | L'OREAL (FR) | 2001-10-23 | — | — | US | claimed |
| EP-0989128-B1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | OREAL (FR) | 2001-03-21 | — | — | EP | claimed |
| EP-0989128-A1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | L'OREAL (FR) | 2000-03-29 | — | — | EP | claimed |
| EP-1728500-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1728500-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-6528650-B2 | Mixture containing coupler | L'OREAL S.A. (FR) | 2003-03-04 | — | — | US | disclosed |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2003-01-30 | — | — | US | disclosed |
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2002-03-21 | — | — | US | disclosed |
| US-6306181-B1 | FOR DYEING HUMAN HAIR | L'OREAL (FR) | 2001-10-23 | — | — | US | disclosed |
| EP-0989128-B1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | OREAL (FR) | 2001-03-21 | — | — | EP | disclosed |
| EP-0989128-A1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | L'OREAL (FR) | 2000-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | KRT18, KMO, H1-5 | HTR2A 96/4885HTR2C 30/4885HTR2B 99/4885 |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | KRT18, KMO, H1-5 | HTR2A 96/4885HTR2C 30/4885HTR2B 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.