Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30214885 | 1.00 | TSHR (0.41) | TSHRMAPK1ALDH1A1VCAM1HSD17B10 | |
| SCHEMBL12434986 | 0.80 | GPR35 (0.55) | TSHRALDH1A1HSD17B10CYP3A4CYP1A2 | |
| SCHEMBL5462320 | 0.80 | GPR35 (0.47) | TSHRMAPK1ALDH1A1VCAM1HSD17B10 | |
| SCHEMBL18829958 | 0.80 | CYP1A2 (0.55) | TSHRMAPK1ALDH1A1VCAM1HSD17B10 | |
| SCHEMBL3612247 | 0.77 | TDP1 (0.54) | TSHRMAPK1ALDH1A1VCAM1HSD17B10 | |
| SCHEMBL25424796 | 0.77 | PDE7A (0.43) | TSHRMAPK1ALDH1A1VCAM1CYP3A4 | |
| SCHEMBL4931946 | 0.77 | CCR6 (0.43) | TSHRMAPK1ALDH1A1VCAM1CYP3A4 | |
| SCHEMBL4969056 | 0.77 | GPR35 (0.65) | MAPK1ALDH1A1HSD17B10CYP1A2RECQL | |
| SCHEMBL25236052 | 0.77 | TTR (0.46) | TSHRMAPK1ALDH1A1VCAM1HSD17B10 | |
| SCHEMBL3293461 | 0.77 | TDP1 (0.41) | TSHRMAPK1ALDH1A1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262806-A1 | INHIBITORS OF NLRP3 | PCT THERAPEUTICS, INC. (US) | 2024-08-08 | — | — | US | disclosed |
| CN-118302417-A | NLRP3 inhibitors | PTC医疗公司 | 2024-07-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240262806-A1 | INHIBITORS OF NLRP3 | NLRP3, NOD1, NLRP1 | TSHR 4642/4885MAPK1 1427/4885ALDH1A1 3173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.