Citric Acid

Citric Acid

SCHEMBL29280333

O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C([O-])CC(O)(CC(=O)O)C(=O)O.[Na+].[Na+].[OH-]

nearest known ligand 0.68

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Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.35
ALDH1A1 P00352 2/20 0.68
CA4 P22748 2/20 0.56
HMGCR P04035 1/20 0.37
CHRM1 P11229 1/20 0.37
TBXA2R P21731 1/20 0.37
ADRA1A P35348 1/20 0.37
TSHR P16473 2/20 0.37
KDM4E B2RXH2 2/20 0.37
LMNA P02545 2/20 0.37
MAPT P10636 1/20 0.37
ALOX15 P16050 1/20 0.37
SLC13A5 Q86YT5 5/20 0.36
CYP2D6 P10635 2/20 0.36
CYP2C19 P33261 1/20 0.36
HIF1A Q16665 1/20 0.36
ACLY P53396 3/20 0.35
CYP1A2 P05177 1/20 0.35
KMT2A Q03164 1/20 0.35
CPT2 P23786 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL3388434 1.00 ALDH1A1 (0.68) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL31171639 0.98 ALDH1A1 (0.65) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL11747873 0.98 ALDH1A1 (0.65) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL25331242 0.98 ALDH1A1 (0.65) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL28939048 0.98 ALDH1A1 (0.65) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL9125740 0.98 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL2235362 0.98 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL10477646 0.98 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL150577 0.98 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R
Citric Acid SCHEMBL73101 0.98 ALDH1A1 (0.71) ALDH1A1CA4HMGCRCHRM1TBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117731579-A Composition for preventing color change and application thereof 西安润玉医疗科技有限公司 2024-03-22 CN disclosed