Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928954 | 0.85 | KDM4E (0.42) | DRD2HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL2929583 | 0.79 | HSD17B10 (0.42) | HDAC1HDAC2KMT2AKDM4EALDH1A1 | |
| SCHEMBL2928566 | 0.75 | HDAC3 (0.49) | DRD2HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL18568294 | 0.70 | SMN1; SMN2 (0.51) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL12993655 | 0.69 | HTT (0.46) | HDAC3NPC1POLBRAB9AMEN1 | |
| SCHEMBL7839301 | 0.68 | HDAC3 (0.47) | DRD2HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL2924855 | 0.68 | KDM4E (0.40) | POLBKMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL24019707 | 0.66 | MEN1 (0.55) | DRD2HRH4NPC1POLBRAB9A | |
| SCHEMBL10820941 | 0.65 | DRD2 (0.62) | DRD2HDAC3HDAC1HDAC4HDAC7 | |
| SCHEMBL915460 | 0.64 | HRH4 (0.55) | HRH4RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6528650-B2 | Mixture containing coupler | L'OREAL S.A. (FR) | 2003-03-04 | — | — | US | claimed |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2003-01-30 | — | — | US | claimed |
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2002-03-21 | — | — | US | claimed |
| US-6306181-B1 | FOR DYEING HUMAN HAIR | L'OREAL (FR) | 2001-10-23 | — | — | US | claimed |
| EP-0989128-B1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | OREAL (FR) | 2001-03-21 | — | — | EP | claimed |
| EP-0989128-A1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | L'OREAL (FR) | 2000-03-29 | — | — | EP | claimed |
| EP-1728500-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1728500-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-6528650-B2 | Mixture containing coupler | L'OREAL S.A. (FR) | 2003-03-04 | — | — | US | disclosed |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2003-01-30 | — | — | US | disclosed |
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | L'OREAL | 2002-03-21 | — | — | US | disclosed |
| US-6306181-B1 | FOR DYEING HUMAN HAIR | L'OREAL (FR) | 2001-10-23 | — | — | US | disclosed |
| EP-0989128-B1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | OREAL (FR) | 2001-03-21 | — | — | EP | disclosed |
| EP-0989128-A1 | 4-Hydroxyindoles kationic and their use for oxidation dyeing of keratinous fibres | L'OREAL (FR) | 2000-03-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032937-A1 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | KRT18, KMO, H1-5 | DRD2 492/4885HDAC3 526/4885HDAC1 701/4885 |
| US-20030019050-A9 | Novel cationic 4-hydroxyindoles, their use for the oxidation dyeing of keratinous fibers, dyeing compositions, and methods of dyeing | KRT18, KMO, H1-5 | DRD2 492/4885HDAC3 526/4885HDAC1 701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.