Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MC5R | P33032 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MC4R | P32245 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27920877 | 0.80 | NR1H4 (0.70) | NR1H4MEN1KMT2AHDAC3HDAC4 | |
| SCHEMBL1520880 | 0.80 | KEAP1 (0.69) | IDO1KEAP1POLBMAPTALOX12 | |
| SCHEMBL1520269 | 0.80 | IDO1 (0.56) | IDO1NPC1RAB9ANR1H4MC5R | |
| SCHEMBL25167256 | 0.79 | IDO1 (0.64) | IDO1NPC1RAB9ANR1H4POLB | |
| SCHEMBL6562324 | 0.79 | IDO1 (0.64) | IDO1NPC1RAB9ANR1H4MAPT | |
| SCHEMBL14859816 | 0.79 | ALDH1A1 (0.71) | IDO1NPC1RAB9ANR1H4POLB | |
| SCHEMBL1520750 | 0.78 | RAB9A (0.73) | IDO1NPC1RAB9APOLBMAPT | |
| SCHEMBL1695082 | 0.77 | NR1H4 (0.58) | IDO1NR1H4MC5RMAPK1MC4R | |
| SCHEMBL20496883 | 0.77 | IDO1 (0.65) | IDO1NPC1RAB9APOLBMAPT | |
| SCHEMBL28378302 | 0.76 | NR1H4 (0.54) | IDO1NR1H4MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |