Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 4/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29814457 | 0.87 | MET (0.45) | GSK3AGSK3BMAP2K2MAP2K1LMNA | |
| SCHEMBL29626138 | 0.82 | MERTK (0.41) | PGRMAPK1GSK3AGSK3BKDM4E | |
| SCHEMBL14967274 | 0.77 | MET (0.46) | GSK3AGSK3BKDM4ELMNATSHR | |
| SCHEMBL14969022 | 0.77 | PGR (0.46) | PGRGSK3AGSK3BKDM4EALDH1A1 | |
| SCHEMBL31016259 | 0.77 | CA12 (0.40) | MAP2K2MAP2K1KDM4EALDH1A1PKM | |
| SCHEMBL29626132 | 0.76 | MET (0.46) | — | |
| SCHEMBL31016255 | 0.76 | PARP1 (0.40) | MAPK1GSK3AGSK3BKDM4EALDH1A1 | |
| SCHEMBL29625543 | 0.75 | KMT2A (0.48) | PGRMAPK1GSK3AGSK3BKDM4E | |
| SCHEMBL29814160 | 0.75 | AXL (0.41) | GSK3AGSK3BMAP2K2MAP2K1 | |
| SCHEMBL30031403 | 0.75 | CA12 (0.39) | KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109348715-A | pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2019-02-15 | — | — | CN | claimed |
| CN-109348715-A | pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2019-02-15 | — | — | CN | disclosed |