Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 3/20 | 0.51 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9570975 | 0.70 | ALDH1A1 (0.50) | ADORA1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11222481 | 0.68 | MAPT (0.45) | FBP1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL773032 | 0.66 | LCK (0.61) | — | |
| SCHEMBL2175442 | 0.66 | SMN1; SMN2 (0.34) | FBP1ALDH1A1LMNASMN1; SMN2RAB9A | |
| SCHEMBL16238270 | 0.66 | RAB9A (0.64) | ALDH1A1NPSR1RXFP1MEN1KMT2A | |
| SCHEMBL11225698 | 0.66 | MAPT (0.43) | FBP1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL1743735 | 0.66 | ALDH1A1 (0.39) | ALDH1A1NPSR1RXFP1MEN1KMT2A | |
| SCHEMBL16742808 | 0.65 | ALDH1A1 (0.34) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL7144220 | 0.65 | MEN1 (0.40) | ALDH1A1LMNANPSR1RXFP1MEN1 | |
| SCHEMBL11224332 | 0.65 | MAPT (0.40) | FBP1ALDH1A1RXFP1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227468-A1 | AMINOTHIAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009068467-A1 | AMINOTHIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-04 | — | — | WO | disclosed |