Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.67 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1520731 | 0.82 | IDO1 (0.67) | IDO1TAAR1ALDH1A1MAPTCNR1 | |
| SCHEMBL2792097 | 0.81 | IDO1 (0.70) | IDO1TAAR1ALDH1A1LMNAMAPT | |
| SCHEMBL2794397 | 0.80 | IDO1 (1.00) | IDO1TAAR1ALDH1A1LMNAMAPT | |
| SCHEMBL2931251 | 0.79 | IDO1 (0.63) | IDO1TAAR1ALDH1A1MAPTCNR1 | |
| SCHEMBL30440127 | 0.79 | TAAR1 (0.49) | TAAR1ALDH1A1LMNAMAPTCNR1 | |
| SCHEMBL1010528 | 0.76 | TAAR1 (0.62) | TAAR1ALDH1A1LMNAMAPTCNR1 | |
| SCHEMBL5117230 | 0.74 | CNR1 (0.59) | TAAR1ALDH1A1LMNAMAPTCNR1 | |
| SCHEMBL28321492 | 0.74 | TAAR1 (0.58) | TAAR1LMNACNR1TP53KMT2A | |
| SCHEMBL14241863 | 0.74 | MTNR1A (0.67) | TAAR1CNR1TP53OPRM1OPRD1 | |
| SCHEMBL7585545 | 0.73 | MAPT (0.66) | TAAR1ALDH1A1LMNAMAPTCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |