Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.59 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554486 | 0.88 | TAAR1 (0.50) | CNR1TAAR1TP53 | |
| SCHEMBL28872233 | 0.87 | CNR1 (0.57) | CNR1TAAR1TP53LMNAALDH1A1 | |
| SCHEMBL30016330 | 0.87 | CNR1 (0.57) | CNR1TAAR1TP53LMNAALDH1A1 | |
| SCHEMBL27895492 | 0.86 | NR4A2 (0.62) | — | |
| SCHEMBL1010528 | 0.85 | TAAR1 (0.62) | CNR1TAAR1TP53LMNAALDH1A1 | |
| SCHEMBL8802955 | 0.84 | ALDH1A1 (0.69) | CNR1TAAR1TP53LMNAALDH1A1 | |
| SCHEMBL23973860 | 0.83 | CNR1 (0.60) | CNR1TAAR1TP53LMNAALDH1A1 | |
| SCHEMBL29699631 | 0.82 | SRC (0.61) | TP53ALDH1A1POLBRAB9A | |
| SCHEMBL3109722 | 0.82 | SRC (0.61) | TP53ALDH1A1POLBRAB9A | |
| SCHEMBL14241863 | 0.82 | MTNR1A (0.67) | CNR1TAAR1TP53OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1894217-B | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors | HOFFMANN LA ROCHE | 2011-09-21 | — | — | CN | disclosed |
| US-20080108814-A1 | Potent and highly selective heteroaromatic inhibitors of neuronal nitric oxide synthase | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-05-08 | — | — | US | disclosed |
| CN-1894217-A | Substituted dibenzo-azepine and benzo-diazepine derivatives useful as gamma-secretase inhibitors | HOFFMANN LA ROCHE (CH) | 2007-01-10 | — | — | CN | disclosed |
| EP-1673347-A1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | F. Hoffman-la Roche AG (CH) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005040126-A1 | SUBSTITUTED DIBENZO-AZEPINE AND BENZO-DIAZEPINE DERIVATIVES USEFUL AS GAMMA-SECRETASE INHIBITORS | F. HOFFMAN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108814-A1 | Potent and highly selective heteroaromatic inhibitors of neuronal nitric oxide synthase | NOS1, NOS2, NOS3 | CNR1 2388/4885TAAR1 1066/4885TP53 2008/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.