Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.42 |
| ▸ | POLA1 | P09884 | 4/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | RXRB | P28702 | 1/20 | 0.37 |
| ▸ | RXRG | P48443 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29292359 | 0.90 | NR1H2 (0.43) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL29292384 | 0.90 | NR1H2 (0.39) | NR1H2NR1H3POLA1PDE4DKARS1 | |
| SCHEMBL29296723 | 0.84 | NR1H2 (0.43) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL29295337 | 0.81 | NR1H2 (0.49) | NR1H2NR1H3POLA1PDE4DKARS1 | |
| SCHEMBL29295648 | 0.81 | NR1H2 (0.35) | NR1H2NR1H3POLA1KARS1 | |
| SCHEMBL21569998 | 0.81 | NR1H2 (0.45) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL29295657 | 0.78 | KMT2A (0.39) | NR1H2NR1H3POLA1POLB | |
| SCHEMBL29295646 | 0.77 | NR1H2 (0.50) | NR1H2NR1H3POLA1PDE4D | |
| SCHEMBL29295301 | 0.77 | NR1H2 (0.50) | NR1H2NR1H3POLA1 | |
| SCHEMBL21569831 | 0.76 | NR1H2 (0.37) | NR1H2NR1H3POLA1PDE4DKARS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |