Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29293271 | 0.73 | KCNH2 (0.36) | KDM4EALDH1A1POLBSLC6A2SLC6A4 | |
| SCHEMBL29293219 | 0.69 | TAAR1 (0.49) | ADRA2CSLC6A4 | |
| SCHEMBL27689434 | 0.69 | HRH3 (0.71) | TMEM97SIGMAR1L3MBTL3L3MBTL1KDM4E | |
| SCHEMBL30596611 | 0.66 | KDM4E (0.71) | SIGMAR1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL28001277 | 0.66 | KCNH2 (0.79) | SIGMAR1L3MBTL1KDM4EALDH1A1HRH3 | |
| SCHEMBL3863293 | 0.66 | L3MBTL3 (0.53) | MAOAMAOBSIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL7304319 | 0.65 | MAOA (0.60) | MAOAMAOBSIGMAR1L3MBTL3L3MBTL1 | |
| SCHEMBL26015376 | 0.65 | SLC6A4 (0.49) | TMEM97SIGMAR1HRH3CHRM2ADRA2C | |
| SCHEMBL24508364 | 0.64 | KDM4E (0.73) | SIGMAR1KDM4EALDH1A1POLBTDP1 | |
| SCHEMBL26508384 | 0.64 | HTR2A (0.65) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |