Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29293219 | 0.81 | TAAR1 (0.49) | SLC6A4 | |
| SCHEMBL21227827 | 0.79 | TAAR1 (0.33) | MAPK1CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL16956502 | 0.75 | KCNH2 (0.42) | KCNH2FLT1FLT4KDRHPGD | |
| SCHEMBL29293424 | 0.74 | DRD2 (0.40) | DRD3 | |
| SCHEMBL426435 | 0.74 | IDO1 (0.56) | HPGDIDO1CYP3A4MAPK1CYP1A2 | |
| SCHEMBL29293547 | 0.73 | MAOA (0.43) | KCNH2KMT2AMAPTSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7988970 | 0.72 | IDO1 (0.54) | HPGDIDO1CYP3A4MAPK1CYP1A2 | |
| SCHEMBL19278265 | 0.72 | FLT1 (0.45) | KCNH2FLT1FLT4KDRHPGD | |
| SCHEMBL8337975 | 0.72 | CYP3A4 (0.40) | KCNH2FLT1FLT4KDRHPGD | |
| SCHEMBL18597323 | 0.72 | CYP3A4 (0.42) | HPGDCYP3A4CYP2C9ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3735411-B1 | 1,3,4,5-TETRAHYDRO-2H-PYRIDO[4,3-B]INDOLE DERIVATIVES FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES LIKE ALZHEIMER`S DISEASE | AC IMMUNE SA (CH) | 2024-07-10 | — | — | EP | disclosed |