Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 11/20 | 0.56 |
| ▸ | POLA1 | P09884 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | SOD1 | P00441 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29295083 | 0.87 | NR1H2 (0.73) | NR1H2NR1H3POLA1SOD1 | |
| SCHEMBL24591989 | 0.87 | NR1H2 (0.62) | NR1H2NR1H3POLA1LMNACYP3A4 | |
| SCHEMBL20561119 | 0.87 | POLA1 (0.71) | NR1H2NR1H3POLA1LMNACYP3A4 | |
| SCHEMBL21569919 | 0.87 | NR1H2 (0.62) | NR1H2NR1H3POLA1LMNACYP3A4 | |
| SCHEMBL2986350 | 0.87 | LMNA (0.65) | NR1H2NR1H3POLA1LMNACYP3A4 | |
| SCHEMBL21552174 | 0.85 | NR1H2 (0.77) | NR1H2NR1H3POLA1SOD1 | |
| SCHEMBL24591823 | 0.84 | SOD1 (0.69) | NR1H2NR1H3POLA1CYP3A4SOD1 | |
| SCHEMBL21569787 | 0.82 | NR1H2 (0.46) | NR1H2NR1H3POLA1LMNACYP3A4 | |
| SCHEMBL29295337 | 0.81 | NR1H2 (0.49) | NR1H2NR1H3POLA1PDE4DSOD1 | |
| Trifluoroacetic Acid SCHEMBL21552217 | 0.81 | POLA1 (0.63) | NR1H2NR1H3POLA1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |