Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2933466 | 0.84 | HPGD (0.66) | L3MBTL1NPC1SMN1; SMN2TSHRHPGD | |
| SCHEMBL2377883 | 0.84 | L3MBTL1 (0.51) | L3MBTL1NPC1USP2SMN1; SMN2TSHR | |
| SCHEMBL4725945 | 0.83 | L3MBTL1 (0.71) | L3MBTL1NPC1USP2SMN1; SMN2TSHR | |
| SCHEMBL10077130 | 0.83 | L3MBTL1 (0.71) | L3MBTL1NPC1TSHRHPGDKMT2A | |
| SCHEMBL2933315 | 0.81 | L3MBTL1 (0.56) | L3MBTL1NPC1TSHRHPGDKMT2A | |
| SCHEMBL15919361 | 0.80 | NPC1 (0.58) | L3MBTL1NPC1TSHRHPGDKMT2A | |
| SCHEMBL8898022 | 0.78 | L3MBTL1 (0.64) | L3MBTL1USP2SMN1; SMN2HPGDKMT2A | |
| SCHEMBL27750807 | 0.74 | NPC1 (0.42) | L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL1156725 | 0.74 | ATM (0.69) | L3MBTL1USP2SMN1; SMN2TSHRKMT2A | |
| SCHEMBL30180028 | 0.73 | NPC1 (0.61) | NPC1TSHRHPGDKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |