Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291574 | 0.82 | PARP1 (0.44) | PRKCQPRKCDPARP1PARP2TNKS | |
| SCHEMBL20255406 | 0.81 | DRD2 (0.45) | PRKCQPRKCDPARP1PARP2TNKS | |
| SCHEMBL29475483 | 0.81 | TRPV6 (0.51) | PARP1PARP2TNKSKMT2AMAP4K4 | |
| SCHEMBL18291711 | 0.81 | MAP4K4 (0.44) | PRKCQPRKCDPARP1PARP2TNKS | |
| SCHEMBL2933977 | 0.81 | TRPV6 (0.51) | PARP1PARP2TNKSKMT2AMAP4K4 | |
| SCHEMBL30786240 | 0.79 | HRH3 (0.52) | HRH3 | |
| SCHEMBL2929383 | 0.79 | LMNA (0.50) | KMT2AHRH3 | |
| SCHEMBL20249124 | 0.78 | KCNH2 (0.47) | PARP1PARP2TNKSKMT2AMAP4K4 | |
| SCHEMBL20037688 | 0.78 | PARP1 (0.42) | PARP1PARP2TNKSKMT2AMAP4K4 | |
| SCHEMBL17646031 | 0.76 | HRH3 (0.53) | HRH3LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |