Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PPID | Q08752 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19726788 | 0.93 | ALDH1A1 (0.61) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL8911820 | 0.89 | ALDH1A1 (0.56) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL18283191 | 0.89 | ALDH1A1 (0.56) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL8337648 | 0.85 | ALDH1A1 (0.57) | LTA4HALDH1A1L3MBTL1MAPTKDM4E | |
| SCHEMBL21107863 | 0.85 | ALDH1A1 (0.49) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL6900506 | 0.84 | ALDH1A1 (0.51) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL4533147 | 0.84 | ALDH1A1 (0.51) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL9998357 | 0.84 | ALDH1A1 (0.49) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL24127602 | 0.83 | LTA4H (0.55) | LTA4HALDH1A1MAPK1L3MBTL1MAPT | |
| SCHEMBL25942983 | 0.83 | LTA4H (0.53) | LTA4HALDH1A1MAPK1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240226106-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES (US) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240226106-A1 | INHIBITORS OF PLASMA KALLIKREIN | KLKB1, KLK5, KLK1 | LTA4H 286/4885ALDH1A1 3041/4885MAPK1 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.