Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.33 |
| ▸ | MME | P08473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14161850 | 0.74 | CCR2 (0.49) | HPGDEPHX1MMEMAPTMAPK1 | |
| SCHEMBL28826594 | 0.72 | CCR2 (0.51) | HPGDEPHX1MAPTMAPK1NPSR1 | |
| SCHEMBL1968938 | 0.71 | TSHR (0.31) | — | |
| SCHEMBL3455744 | 0.70 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL12020314 | 0.69 | HPGD (0.46) | HPGDEPHX1MAPTMAPK1NPSR1 | |
| SCHEMBL20194660 | 0.68 | HPGD (0.55) | HPGDEPHX1MAPTMAPK1NPSR1 | |
| SCHEMBL3835575 | 0.67 | MAPT (0.44) | HPGDEPHX1MMEMAPTPOLB | |
| SCHEMBL1770504 | 0.65 | — | — | |
| SCHEMBL1464813 | 0.64 | EPHX1 (0.43) | HPGDEPHX1MMEMAPTMAPK1 | |
| SCHEMBL12469141 | 0.64 | EPHX2 (0.42) | HPGDEPHX1MAPTPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227467-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009071476-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-11 | — | — | WO | disclosed |