Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29311604 | 0.84 | HTR7 (0.45) | HTR7CYP1A2CYP2D6CYP2C19UTS2R | |
| SCHEMBL25319735 | 0.82 | HTR7 (0.54) | HTR7CYP1A2CYP2D6CYP2C19UTS2R | |
| SCHEMBL23966847 | 0.75 | AAK1 (0.40) | HTR2AKDM4EALDH1A1 | |
| SCHEMBL25321839 | 0.71 | KDM4E (0.49) | HTR7CYP1A2CYP2D6CYP2C19ROCK2 | |
| SCHEMBL31078181 | 0.71 | KDM4E (0.49) | HTR7CYP1A2CYP2D6CYP2C19ROCK2 | |
| SCHEMBL7399293 | 0.70 | HTR7 (0.60) | HTR7CYP1A2CYP2D6CYP2C19UTS2R | |
| SCHEMBL23875588 | 0.68 | HTR7 (0.53) | HTR7CYP1A2CYP2D6CYP2C19UTS2R | |
| SCHEMBL30058042 | 0.68 | HTR7 (0.53) | HTR7CYP1A2CYP2D6CYP2C19UTS2R | |
| SCHEMBL1986857 | 0.68 | HTR7 (0.49) | HTR7CYP1A2CYP2D6CYP2C19UTS2R | |
| SCHEMBL25794425 | 0.68 | HTR7 (0.49) | HTR7CYP1A2CYP2D6CYP2C19UTS2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024141443-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS SIK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-07-04 | — | — | WO | disclosed |