Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30986469 | 1.00 | MAP3K12 (0.37) | MAP3K12HRH3KCNH2LRRK2ABCG2 | |
| SCHEMBL29311693 | 0.83 | MAP3K12 (0.39) | MAP3K12HRH3KCNH2 | |
| SCHEMBL25318985 | 0.80 | CHRNB2 (0.37) | KCNH2 | |
| SCHEMBL30508902 | 0.80 | CHRNB2 (0.37) | KCNH2 | |
| SCHEMBL31110184 | 0.78 | CHRNB2 (0.40) | — | |
| SCHEMBL30986545 | 0.78 | HRH3 (0.42) | HRH3KCNH2LRRK2 | |
| SCHEMBL17654119 | 0.75 | LMNA (0.55) | — | |
| SCHEMBL16292286 | 0.74 | HRH3 (0.44) | MAP3K12HRH3KCNH2 | |
| SCHEMBL16292314 | 0.74 | HRH3 (0.44) | MAP3K12HRH3KCNH2 | |
| SCHEMBL12949577 | 0.74 | LOX (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024141443-A1 | BENZIMIDAZOLE DERIVATIVES USEFUL AS SIK MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2024-07-04 | — | — | WO | disclosed |