Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KMO | O15229 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25318985 | 1.00 | CHRNB2 (0.37) | CHRNB2CHRNA4ALDH1A1GAAMAPT | |
| SCHEMBL31110184 | 0.82 | CHRNB2 (0.40) | CHRNB2CHRNA4ALDH1A1GAAMAPT | |
| SCHEMBL29311685 | 0.80 | MAP3K12 (0.37) | KCNH2 | |
| SCHEMBL30986469 | 0.80 | MAP3K12 (0.37) | KCNH2 | |
| SCHEMBL25319182 | 0.78 | BCAT2 (0.42) | — | |
| SCHEMBL12949577 | 0.78 | LOX (0.41) | CHRNB2CHRNA4ALDH1A1GAAMAPT | |
| SCHEMBL20923376 | 0.75 | KMT2A (0.38) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL30138343 | 0.75 | KMT2A (0.38) | CHRNB2CHRNA4KMT2A | |
| SCHEMBL30986478 | 0.75 | HRH1 (0.44) | CHRNB2CHRNA4KCNH2 | |
| SCHEMBL11908109 | 0.75 | HRH1 (0.44) | CHRNB2CHRNA4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466258-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-11-27 | — | — | EP | disclosed |
| CN-118591534-A | Novel benzimidazole pyridine derivatives | 豪夫迈·罗氏有限公司 | 2024-09-03 | — | — | CN | disclosed |
| WO-2023139085-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |