SCHEMBL2931188

SCHEMBL2931188

Cc1sc(=S)n(Cc2ccccc2)c1C

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.58
MAPK1 P28482 2/20 0.58
TDP1 Q9NUW8 1/20 0.58
LMNA P02545 3/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
MEN1 O00255 3/20 0.51
MAPT P10636 3/20 0.51
KMT2A Q03164 3/20 0.51
KDM4E B2RXH2 4/20 0.46
POLB P06746 1/20 0.46
NPSR1 Q6W5P4 2/20 0.46
TSHR P16473 2/20 0.46
RECQL P46063 1/20 0.44
GSK3B P49841 4/20 0.44
GSK3A P49840 2/20 0.44
CCNB2 O95067 1/20 0.44
CDK1 P06493 1/20 0.44
CCNB1 P14635 1/20 0.44
CCNB3 Q8WWL7 1/20 0.44
HPGD P15428 3/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4616447 0.79 GSK3B (0.56) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL4616037 0.75 ALDH1A1 (0.46) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL4616035 0.75 ALDH1A1 (0.46) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL17446112 0.72 ALDH1A1 (0.41) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL11780045 0.71 L3MBTL1 (0.65) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL5282965 0.70 TSHR (0.44) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL5282968 0.70 TSHR (0.44) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL29267620 0.69 LMNA (0.60) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL6521231 0.68 KDM4E (0.59) ALDH1A1MAPK1TDP1LMNASMN1; SMN2
SCHEMBL5283987 0.65 KDM4E (0.55) ALDH1A1MAPK1TDP1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2227233-A2 IDO INHIBITORS Newlink Genetics (US) 2010-09-15 EP claimed
WO-2009073620-A2 IDO INHIBITORS NEWLINK GENETICS (US) 2009-06-11 WO claimed