Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 10/20 | 0.34 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | MET | P08581 | 3/20 | 0.33 |
| ▸ | TEK | Q02763 | 3/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3759308 | 0.85 | AURKA (0.35) | BRAFKDRAURKAMETTEK | |
| SCHEMBL2934749 | 0.81 | MET (0.40) | PDGFRBPDGFRABRAFKDRMET | |
| SCHEMBL2931209 | 0.79 | BRAF (0.44) | PDGFRABRAFKDREGFRBTK | |
| SCHEMBL29397182 | 0.75 | BRAF (0.43) | BRAFKDREGFRABL1 | |
| SCHEMBL3751510 | 0.75 | BRAF (0.43) | BRAFKDREGFRABL1 | |
| SCHEMBL28518969 | 0.74 | MET (0.41) | PDGFRAKDRMET | |
| SCHEMBL14543319 | 0.70 | ACHE (0.39) | ABL1LMNAPKMRAB9A | |
| SCHEMBL2933076 | 0.69 | BRAF (0.71) | BRAF | |
| SCHEMBL9909774 | 0.69 | TNKS (0.54) | KDRAURKAMETTEKAURKB | |
| SCHEMBL114170 | 0.69 | MCL1 (0.39) | NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |