Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.36 |
| ▸ | LIPE | Q05469 | 7/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314047 | 0.90 | LIPE (0.36) | POLQLIPEIMPDH2IMPDH1AAK1 | |
| SCHEMBL29314049 | 0.88 | POLQ (0.34) | POLQLIPEIMPDH2IMPDH1AAK1 | |
| SCHEMBL29314044 | 0.83 | POLQ (0.42) | POLQLIPEIMPDH2IMPDH1AAK1 | |
| SCHEMBL29314384 | 0.72 | POLQ (0.52) | POLQLIPEALDH1A1KDM4ENPC1 | |
| SCHEMBL29313969 | 0.71 | POLQ (0.37) | POLQLIPEALDH1A1L3MBTL1LMNA | |
| SCHEMBL30847644 | 0.70 | POLQ (0.41) | POLQLIPEMEN1KMT2AALDH1A1 | |
| SCHEMBL29314067 | 0.69 | POLQ (0.43) | POLQLIPE | |
| SCHEMBL29314388 | 0.69 | POLQ (0.50) | POLQLIPEMEN1KMT2AALDH1A1 | |
| SCHEMBL30847596 | 0.69 | POLQ (0.50) | POLQLIPEMEN1KMT2AMAPK1 | |
| SCHEMBL31009186 | 0.67 | POLQ (0.44) | POLQLIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |