SCHEMBL29314307

SCHEMBL29314307

CC(C)N(C(=O)Oc1c(-n2cc[nH]c2=S)cc(C(F)(F)F)cc1C(F)(F)F)c1ccc(F)c(Cl)n1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.32
POLQ O75417 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29314305 0.91 POLQ (0.30) POLQ
SCHEMBL29313854 0.90 POLB (0.31)
SCHEMBL29314315 0.86
SCHEMBL29314308 0.85 GAA (0.32) GAAPOLQ
SCHEMBL29314303 0.84 POLQ (0.33) GAAPOLQ
SCHEMBL29313853 0.81 ALDH1A1 (0.31)
SCHEMBL29313855 0.78 POLQ (0.37) POLQ
SCHEMBL29314312 0.77
SCHEMBL29313852 0.77 POLQ (0.41) POLQ
SCHEMBL29313863 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024147972-A2 DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-07-11 WO disclosed