Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 5/20 | 0.41 |
| ▸ | LIPE | Q05469 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.32 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31009145 | 0.90 | POLQ (0.44) | POLQLIPESCN8ASCN10AKMT2A | |
| SCHEMBL29314474 | 0.90 | POLQ (0.44) | POLQLIPESCN8ASCN10AKMT2A | |
| SCHEMBL29314303 | 0.88 | POLQ (0.33) | POLQALDH1A1SCN8ASCN10ATACR1 | |
| SCHEMBL31009165 | 0.84 | POLQ (0.46) | POLQSCN8ASCN10A | |
| SCHEMBL29313853 | 0.83 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL29313854 | 0.83 | POLB (0.31) | — | |
| SCHEMBL29313855 | 0.83 | POLQ (0.37) | POLQ | |
| SCHEMBL29313860 | 0.82 | POLQ (0.34) | POLQ | |
| SCHEMBL29313609 | 0.78 | POLQ (0.40) | POLQLIPE | |
| SCHEMBL29314384 | 0.78 | POLQ (0.52) | POLQLIPEALDH1A1TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |