Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217209 | 0.85 | TP53 (0.71) | HSD11B1ALDH1A1TP53ATMKMT2A | |
| SCHEMBL23978381 | 0.85 | GNAI3 (0.59) | NPC1HSD11B1ALDH1A1TP53ATM | |
| SCHEMBL23205790 | 0.85 | NPC1 (0.59) | NPC1HSD11B1ALDH1A1TP53ATM | |
| SCHEMBL3952911 | 0.83 | HSD11B1 (0.70) | HSD11B1ALDH1A1TP53ATMKMT2A | |
| SCHEMBL22602813 | 0.83 | HSD11B1 (0.70) | HSD11B1ALDH1A1TP53ATMKMT2A | |
| SCHEMBL5517503 | 0.83 | HSD11B1 (0.70) | HSD11B1ALDH1A1TP53ATMKMT2A | |
| SCHEMBL22874699 | 0.83 | HSD11B1 (0.69) | HSD11B1ALDH1A1TP53ATMKMT2A | |
| SCHEMBL8258158 | 0.81 | ALDH1A1 (0.58) | NPC1HSD11B1ALDH1A1ATMKMT2A | |
| SCHEMBL22874700 | 0.81 | HSD11B1 (0.63) | HSD11B1ALDH1A1TP53ATMKMT2A | |
| SCHEMBL22874698 | 0.80 | HSD11B1 (0.66) | HSD11B1ALDH1A1TP53ATMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4400172-A2 | PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS | Incyte Holdings Corporation (US) | 2024-07-17 | — | — | EP | disclosed |