SCHEMBL29314779

SCHEMBL29314779

CNc1ncc(C#N)c(-c2c(C)noc2C)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 2/20 0.42
CYP1A2 P05177 3/20 0.41
CYP3A4 P08684 2/20 0.41
HSD17B10 Q99714 2/20 0.41
ALOX15 P16050 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
CCNT1 O60563 12/20 0.41
CCNA2 P20248 12/20 0.41
CDK2 P24941 12/20 0.41
CDK9 P50750 12/20 0.41
CCNA1 P78396 6/20 0.41
CDK1 P06493 5/20 0.39
KDR P35968 2/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
KMT2A Q03164 1/20 0.39
HIF1A Q16665 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23336389 0.79 BRD4 (0.45) BRD4CYP1A2CYP3A4HSD17B10ALOX15
SCHEMBL29314767 0.75 CCNT1 (0.40) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL13523666 0.74 KDM4E (0.41) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL29315373 0.73 KDR (0.48) HSD17B10ALOX15CCNT1CCNA2CDK2
SCHEMBL29315239 0.70 HSP90AB1 (0.42) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL22684859 0.70 CCNT1 (0.54) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL29314732 0.67 KDR (0.61) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL25598891 0.66 CSNK1A1 (0.42) CYP1A2CYP2C9CYP2C19CCNT1CCNA2
SCHEMBL13587064 0.66 AURKA (0.37) CCNT1CCNA2CDK2CDK9CCNA1
SCHEMBL29314862 0.66 ADORA1 (0.64) HSD17B10ALOX15CDK1KDRALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3782986-B1 HETEROCYCLIC COMPOUND TAKEDA PHARMACEUTICALS CO (JP) 2024-07-10 EP disclosed