SCHEMBL29314927

SCHEMBL29314927

CP(C)(=O)c1ccc(-c2cnc3nnn(C(Cl)c4ccc5nccn5c4)c3n2)cc1

nearest known ligand 0.56

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MET P08581 20/20 0.56
NQO2 P16083 1/20 0.56
PDE4C Q08493 2/20 0.38
PDE4D Q08499 2/20 0.38
PDE3B Q13370 2/20 0.38
PDE3A Q14432 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30948875 0.90 MET (0.70) METNQO2PDE4CPDE4DPDE3B
SCHEMBL22109176 0.90 MET (0.70) METNQO2PDE4CPDE4DPDE3B
SCHEMBL29314973 0.84 MET (0.60) METNQO2PDE4CPDE4DPDE3B
SCHEMBL22109369 0.80 MET (0.66) METNQO2PDE4CPDE4DPDE3B
SCHEMBL22109376 0.79 MET (0.65) METNQO2PDE4CPDE4DPDE3B
SCHEMBL29314877 0.79 MET (0.56) METPDE4CPDE4DPDE3BPDE3A
SCHEMBL30948861 0.78 MET (0.75) METNQO2
SCHEMBL22109392 0.78 MET (0.75) METNQO2
SCHEMBL29315257 0.78 MET (0.63) METNQO2PDE4CPDE4DPDE3B
SCHEMBL22109189 0.78 MET (0.47) METNQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3893872-B1 ORGANOPHOSPHORUS-SUBSTITUTED COMPOUNDS AS C-MET INHIBITORS AND THERAPEUTIC USES THEREOF BETA PHARMA INC (US) 2024-07-17 EP disclosed