Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 14/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30662127 | 0.80 | CSNK1A1 (0.45) | LRRK2AURKAIRAK4AXL | |
| SCHEMBL21409882 | 0.80 | CSNK1A1 (0.45) | LRRK2AURKAIRAK4AXL | |
| SCHEMBL29315908 | 0.80 | LRRK2 (0.40) | LRRK2PRKCQPRKCDIRAK4CYP2C9 | |
| SCHEMBL29315748 | 0.77 | LRRK2 (0.39) | LRRK2PRKCQPRKCDIRAK4 | |
| SCHEMBL29316281 | 0.77 | LRRK2 (0.40) | LRRK2PRKCQPRKCDIRAK4AXL | |
| SCHEMBL29315109 | 0.76 | PRKCQ (0.40) | LRRK2AURKAPRKCQPRKCD | |
| SCHEMBL29313573 | 0.74 | LRRK2 (0.47) | LRRK2PRKCQ | |
| SCHEMBL29313719 | 0.72 | AURKA (0.38) | LRRK2AURKASYK | |
| SCHEMBL23262220 | 0.72 | PRKCQ (0.51) | LRRK2PRKCQPRKCDAXLTYRO3 | |
| SCHEMBL21162418 | 0.71 | LRRK2 (0.50) | LRRK2PRKCQPRKCDIRAK4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782986-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-10 | — | — | EP | disclosed |