Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.51 |
| ▸ | CFTR | P13569 | 5/20 | 0.50 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.39 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863532 | 0.85 | CFTR (0.55) | NOTUMCFTRCES2SOS1P2RX1 | |
| SCHEMBL30343770 | 0.82 | NOTUM (0.50) | NOTUMCFTRCES2SOS1P2RX1 | |
| SCHEMBL25574138 | 0.79 | CES2 (0.47) | CES2GPR35KDM4EXDH | |
| SCHEMBL1530144 | 0.78 | NR5A2 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2002005 | 0.78 | CFTR (0.69) | NOTUMCFTRCES2CA12CA1 | |
| SCHEMBL1995951 | 0.78 | CES2 (0.71) | NOTUMCFTRCES2TMPRSS4KDM4E | |
| SCHEMBL30314144 | 0.78 | NR5A2 (0.55) | CA12CA1CA2CA7CA9 | |
| SCHEMBL14880120 | 0.77 | CES2 (0.50) | CES2P2RX1KDM4EGAA | |
| SCHEMBL16056579 | 0.77 | CYP1A2 (0.46) | NOTUMCFTRGPR35POLBTDP1 | |
| SCHEMBL25355994 | 0.77 | CFTR (0.50) | NOTUMCFTRCES2SOS1P2RX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |
| US-20230180754-A1 | HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS | BASF SE (DE) | 2023-06-15 | — | — | US | disclosed |
| EP-4149936-A1 | HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS | BASF SE (DE) | 2023-03-22 | — | — | EP | disclosed |
| WO-2021228594-A1 | HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS | BASF SE (DE) | 2021-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230180754-A1 | HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS | DDT, ACHE, CYCS | NOTUM 283/4885CFTR 4430/4885CES2 1620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.