Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14389809 | 0.89 | S1PR5 (0.33) | S1PR5S1PR1PTGESALOX5PPARG | |
| SCHEMBL9979284 | 0.87 | TLR4 (0.32) | OPRM1OPRK1OPRL1 | |
| SCHEMBL20808415 | 0.85 | OPRM1 (0.35) | OPRM1OPRK1OPRL1 | |
| SCHEMBL20808413 | 0.85 | OPRM1 (0.35) | OPRM1OPRK1OPRL1 | |
| SCHEMBL20797235 | 0.85 | OPRM1 (0.35) | OPRM1OPRK1OPRL1 | |
| SCHEMBL2882641 | 0.84 | OPRM1 (0.32) | OPRM1OPRK1OPRL1PDK2 | |
| SCHEMBL13235182 | 0.84 | OPRM1 (0.32) | OPRM1OPRK1OPRL1PDK2 | |
| SCHEMBL4409430 | 0.84 | S1PR5 (0.35) | S1PR5S1PR1 | |
| SCHEMBL421950 | 0.84 | SCN9A (0.34) | S1PR5S1PR1 | |
| SCHEMBL2882773 | 0.83 | OPRM1 (0.32) | OPRM1OPRK1OPRL1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852429-B1 | Hexahydro dibenzofuran derivatives | MERCK PATENT GMBH (DE) | 2010-09-15 | — | — | EP | disclosed |
| US-7417157-B2 | Hexahydrodibenzofuran derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-08-26 | — | — | US | disclosed |
| US-7417157-B2 | Hexahydrodibenzofuran derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-08-26 | — | — | US | disclosed |
| US-7417157-B2 | Hexahydrodibenzofuran derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-08-26 | — | — | US | disclosed |
| EP-1852429-A1 | Hexahydro dibenzofuran derivatives | Merck Patent GmbH (DE) | 2007-11-07 | — | — | EP | disclosed |
| US-20070247585-A1 | Hexahydrodibenzofuran derivatives | MERCK PATENT GMBH | 2007-10-25 | — | — | US | disclosed |
| US-20070247585-A1 | Hexahydrodibenzofuran derivatives | MERCK PATENT GMBH | 2007-10-25 | — | — | US | disclosed |
| US-20070247585-A1 | Hexahydrodibenzofuran derivatives | MERCK PATENT GMBH | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070247585-A1 | Hexahydrodibenzofuran derivatives | HEXD, CFD, EDF1 | S1PR5 3313/4885S1PR1 3488/4885PTGES 4837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.