Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16248110 | 0.81 | KDM4E (0.33) | SMO | |
| SCHEMBL265343 | 0.80 | KMT2A (0.43) | KMT2A | |
| SCHEMBL29695061 | 0.78 | SCN10A (0.33) | — | |
| SCHEMBL29108369 | 0.78 | SCN10A (0.33) | — | |
| SCHEMBL16248111 | 0.74 | KDM4E (0.32) | — | |
| SCHEMBL7845107 | 0.73 | CCR1 (0.42) | PDE2AAKT1AKT2SMOKMT2A | |
| SCHEMBL14236551 | 0.71 | ADRA2A (0.39) | PDE2AAKT1AKT2SMOKMT2A | |
| SCHEMBL20985293 | 0.71 | NOS3 (0.48) | PDE2AAKT1AKT2 | |
| SCHEMBL24129962 | 0.69 | PDE2A (0.38) | PDE2AAKT1AKT2SMOKMT2A | |
| SCHEMBL11971888 | 0.69 | PDE2A (0.38) | PDE2AAKT1AKT2SMOKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |