Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.69 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MC4R | P32245 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7447200 | 0.82 | CYP2A13 (0.70) | HTR6CYP2A13ALDH1A1KDM4ELMNA | |
| SCHEMBL18356563 | 0.81 | ALDH1A1 (0.71) | HTR6CYP2A13ALDH1A1KDM4ELMNA | |
| SCHEMBL2935951 | 0.80 | MEN1 (0.52) | HTR6ALDH1A1KDM4ECHRNA7POLB | |
| SCHEMBL11891934 | 0.79 | KMT2A (0.73) | HTR6CYP2A13ALDH1A1KDM4ELMNA | |
| SCHEMBL6818375 | 0.79 | ALDH1A1 (0.69) | HTR6CYP2A13ALDH1A1KDM4ELMNA | |
| SCHEMBL13469106 | 0.79 | MC4R (0.58) | HTR6ALDH1A1KDM4EMC4RCHRNA7 | |
| SCHEMBL8162127 | 0.79 | KDM4E (0.66) | CYP2A13ALDH1A1KDM4ELMNAATM | |
| SCHEMBL14986322 | 0.78 | ALDH1A1 (0.68) | HTR6CYP2A13ALDH1A1KDM4ELMNA | |
| SCHEMBL3412153 | 0.78 | MC4R (0.56) | HTR6ALDH1A1KDM4ELMNAMC4R | |
| SCHEMBL17706256 | 0.78 | MC4R (0.56) | HTR6ALDH1A1KDM4ELMNAMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |