Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753873 | 0.83 | MEN1 (0.53) | MEN1KMT2APOLBHTR6KDM4E | |
| SCHEMBL2931838 | 0.80 | HTR6 (0.69) | POLBHTR6KDM4ECYP3A4CYP2D6 | |
| SCHEMBL30573473 | 0.75 | CHRM2 (0.70) | MEN1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL13559793 | 0.74 | SIGMAR1 (0.65) | MEN1KMT2AKDM4ECYP2D6ALDH1A1 | |
| SCHEMBL22169121 | 0.73 | DRD2 (0.52) | MEN1KMT2APOLBHTR6KDM4E | |
| SCHEMBL5265567 | 0.71 | MEN1 (0.54) | MEN1KMT2APOLBHTR6KDM4E | |
| SCHEMBL19561871 | 0.71 | CHRNA7 (0.49) | KMT2APOLBHTR6KDM4ECYP3A4 | |
| SCHEMBL23536830 | 0.71 | GABRA1 (0.52) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1364220 | 0.71 | MEN1 (0.41) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30525679 | 0.71 | MEN1 (0.41) | MEN1KMT2AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |