Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 3/20 | 0.49 |
| ▸ | CASP6 | P55212 | 3/20 | 0.49 |
| ▸ | CCR1 | P32246 | 3/20 | 0.46 |
| ▸ | CCR5 | P51681 | 3/20 | 0.46 |
| ▸ | CCR8 | P51685 | 3/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.38 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2268452 | 0.86 | NOS3 (0.47) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL2270856 | 0.82 | HSP90AA1 (0.52) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL24916289 | 0.81 | NSD2 (0.50) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL10290496 | 0.81 | NSD2 (0.50) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL2265999 | 0.80 | NSD2 (0.41) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL11545634 | 0.80 | NSD2 (0.41) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL13819411 | 0.76 | NSD2 (0.46) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL11545025 | 0.76 | CCR1 (0.48) | NSD2CASP6CCR1CCR5CCR8 | |
| SCHEMBL11544523 | 0.75 | KDM4E (0.53) | CASP7KDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL11067804 | 0.74 | MEN1 (0.44) | NSD2CASP6CCR1CCR5CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9872849-B2 | Diterpenoid membranolide compounds having anti-leishmania activity and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2018-01-23 | — | — | US | claimed |
| US-20160030388-A1 | DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-02-04 | — | — | US | claimed |
| US-9872849-B2 | Diterpenoid membranolide compounds having anti-leishmania activity and uses thereof | UNIVERSITY OF SOUTH FLORIDA (US) | 2018-01-23 | — | — | US | disclosed |
| US-20160030388-A1 | DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-02-04 | — | — | US | disclosed |
| US-9028562-B2 | Dye composition using a 2-hydroxynaphthalene, (acylamino)phenol or quinoline coupler in a fatty-substance-rich medium, dyeing process and device therefor | L'OREAL (FR) | 2015-05-12 | — | — | US | disclosed |
| US-9028562-B2 | Dye composition using a 2-hydroxynaphthalene, (acylamino)phenol or quinoline coupler in a fatty-substance-rich medium, dyeing process and device therefor | L'OREAL (FR) | 2015-05-12 | — | — | US | disclosed |
| US-8809368-B2 | Compounds affecting gap junction activity | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-08-19 | — | — | US | disclosed |
| US-8809368-B2 | Compounds affecting gap junction activity | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-08-19 | — | — | US | disclosed |
| US-20140041133-A1 | DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR | L'OREAL (FR) | 2014-02-13 | — | — | US | disclosed |
| US-20140041133-A1 | DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR | L'OREAL (FR) | 2014-02-13 | — | — | US | disclosed |
| EP-2081906-B1 | SITAMAQUINE TOSYLATE FOR THE TREATMENT OF LEISHMANIASIS | GLAXO GROUP LTD (GB) | 2010-09-22 | — | — | EP | disclosed |
| US-6313126-B1 | FOR THRERAPY OF DISORDERS ASSOCIATED WITH DYSFUNCTION IN SEROTONERGIC NEUROTRANSMISSION, INCLUDING DEPRESSION AND ANXIETY | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | disclosed |
| EP-1147083-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000040554-A1 | ARYLPIPERAZINYL-CYCLOHEXYL INDOLE DERIVATIVES FOR THE TREATMENT OF DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | disclosed |
| WO-1997006161-A1 | ANTICOCCIDIAL 8-AMINOQUINOLINE DERIVATIVES | PFIZER LIMITED (GB) | 1997-02-20 | — | — | WO | disclosed |
| US-4659708-A | Anti-leishmanial lepidine derivatives | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1987-04-21 | — | — | US | disclosed |
| US-4302459-A | Liposome carriers in leishmaniasis chemotherapy with 8-aminoquinoline derivatives | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1981-11-24 | — | — | US | disclosed |
| US-4209519-A | 4-METHYL-6-METHOXY-8-AMINOQUINONE DERIVATIVES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1980-06-24 | — | — | US | disclosed |
| US-4209519-A | 4-METHYL-6-METHOXY-8-AMINOQUINONE DERIVATIVES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1980-06-24 | — | — | US | disclosed |
| US-4167638-A | Process for production of 8-NHR quinolines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1979-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160030388-A1 | DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF | LSS, GYPA, STING1 | NSD2 3720/4885CASP6 747/4885CCR1 3962/4885 |
| US-20140041133-A1 | DYE COMPOSITION USING A 2-HYDROXYNAPHTHALENE, (ACYLAMINO)PHENOL OR QUINOLINE COUPLER IN A FATTY-SUBSTANCE-RICH MEDIUM, DYEING PROCESS AND DEVICE THEREFOR | HADHB, HADH, FABP4 | NSD2 754/4885CASP6 2343/4885CCR1 4606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.