SCHEMBL29322769

SCHEMBL29322769

O=C1CCC(c2coc3ccc(NC(=O)CN4CCNCC4)cc23)C(=O)N1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 7/20 0.42
DDB1 Q16531 6/20 0.42
SMN1; SMN2 Q16637 2/20 0.38
KHK P50053 1/20 0.38
ALDH1A1 P00352 3/20 0.37
GSPT1 P15170 2/20 0.37
POLB P06746 1/20 0.37
JAK3 P52333 1/20 0.36
MAPK1 P28482 1/20 0.36
ADORA2A P29274 1/20 0.36
KDM4E B2RXH2 2/20 0.36
ATM Q13315 1/20 0.36
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
HPGD P15428 1/20 0.35
HTT P42858 1/20 0.35
KMT2A Q03164 1/20 0.35
HSD17B10 Q99714 1/20 0.35
DRD4 P21917 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29322820 0.93 CRBN (0.42) CRBNDDB1SMN1; SMN2KHKALDH1A1
SCHEMBL29322766 0.84 DDB1 (0.48) CRBNDDB1ALDH1A1KDM4ENPC1
SCHEMBL23119737 0.84 CRBN (0.40) CRBNDDB1GSPT1
SCHEMBL23119831 0.84 CRBN (0.41) CRBNDDB1SMN1; SMN2ALDH1A1GSPT1
SCHEMBL29322788 0.83 CRBN (0.42) CRBNDDB1SMN1; SMN2ALDH1A1GSPT1
SCHEMBL27064743 0.83 CRBN (0.37) CRBNDDB1GSPT1
SCHEMBL23119736 0.83 KDM4E (0.43) CRBNDDB1SMN1; SMN2ALDH1A1GSPT1
SCHEMBL31355822 0.80 TERT (0.44)
SCHEMBL29323527 0.80 KDM4E (0.38) CRBNDDB1KHKALDH1A1KDM4E
SCHEMBL23119852 0.80 DRD2 (0.39) CRBNDDB1GSPT1POLBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400499-A1 GLUTARIMIDE COMPOUND AND USE THEREOF Medshine Discovery Inc. (CN) 2024-07-17 EP disclosed