Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 2/20 | 0.53 |
| ▸ | MGLL | Q99685 | 2/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | VEGFA | P15692 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27167164 | 0.84 | GPR183 (0.48) | GPR183MGLLMMP1MMP9MMP13 | |
| SCHEMBL15264271 | 0.84 | STS (0.50) | GPR183MGLLMMP1MMP9MMP13 | |
| SCHEMBL16528665 | 0.83 | VEGFA (0.42) | MGLLMMP1MMP9MMP13ADAM17 | |
| SCHEMBL19974330 | 0.82 | CYP2D6 (0.53) | GPR183MGLLALDH1A1MAPTVEGFA | |
| SCHEMBL11949129 | 0.81 | ALDH1A1 (0.48) | ALDH1A1KDM4EPKM | |
| SCHEMBL10039879 | 0.81 | ALDH1A1 (0.62) | ALDH1A1LMNAMAPTSMN1; SMN2FAAH | |
| SCHEMBL23783427 | 0.81 | MMP1 (0.47) | MMP1MMP9MMP13ADAM17ALDH1A1 | |
| SCHEMBL1632715 | 0.81 | KDM4E (0.58) | MGLLALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL16528206 | 0.81 | MAPK1 (0.43) | MMP1MMP9MMP13ADAM17ALDH1A1 | |
| SCHEMBL29632726 | 0.80 | TBK1 (0.46) | VEGFAEGLN1CHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |