Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.42 |
| ▸ | AR | P10275 | 7/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603589 | 0.85 | P2RX3 (0.49) | P2RX3P2RX2ARIMPDH2IMPDH1 | |
| SCHEMBL29328285 | 0.82 | AR (0.37) | P2RX3P2RX2ARKDM4EUSP2 | |
| SCHEMBL12041224 | 0.81 | TRPV4 (0.42) | P2RX3P2RX2ARALDH1A1TRPV4 | |
| SCHEMBL18068019 | 0.80 | TRPV4 (0.41) | ARTRPV4CYP11B1CYP11B2 | |
| SCHEMBL3425063 | 0.80 | KDM4E (0.48) | ARIMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL11963120 | 0.80 | TRPV4 (0.50) | ARIMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL29328225 | 0.79 | P2RX3 (0.42) | P2RX3P2RX2ARIMPDH2IMPDH1 | |
| SCHEMBL16918776 | 0.79 | P2RX3 (0.42) | P2RX3P2RX2ARIMPDH2IMPDH1 | |
| SCHEMBL15646608 | 0.77 | KDM4E (0.42) | ARIMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL13748193 | 0.77 | P2RX3 (0.58) | P2RX3P2RX2ARIMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | P2RX3 4454/4885P2RX2 3777/4885AR 3185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.