SCHEMBL29329040

SCHEMBL29329040

COc1ccc(Cn2nc(C(F)(F)F)cc2Cc2cccc(C(F)(F)F)n2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 1/20 0.40
GRIN2B Q13224 1/20 0.40
NPBWR1 P48145 2/20 0.39
PTGS1 P23219 3/20 0.39
PTGS2 P35354 3/20 0.39
AKR1C3 P42330 1/20 0.38
AKR1C2 P52895 1/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
FABP4 P15090 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
CYP2C9 P11712 1/20 0.38
TSHR P16473 1/20 0.38
CYP2C19 P33261 1/20 0.38
THPO P40225 1/20 0.38
BLM P54132 1/20 0.38
PMP22 Q01453 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30999698 1.00 GRIN1 (0.40) GRIN1GRIN2BNPBWR1PTGS1PTGS2
SCHEMBL287956 0.80 PTGS2 (0.44) GRIN1GRIN2BNPBWR1PTGS1PTGS2
SCHEMBL25711702 0.78 PTGS1 (0.42) GRIN1GRIN2BNPBWR1PTGS1PTGS2
SCHEMBL1197408 0.76 PTGS2 (0.50) GRIN1GRIN2BNPBWR1PTGS1PTGS2
SCHEMBL1197409 0.76 KDM4E (0.52) NPBWR1PTGS1PTGS2TP53MAPT
SCHEMBL27977409 0.75 PTGS2 (0.44) GRIN1GRIN2BNPBWR1PTGS1PTGS2
SCHEMBL2686354 0.73 PTGER4 (0.46) AKR1C3TP53FABP4TSHR
SCHEMBL25225321 0.72 MAPT (0.44) AKR1C3AKR1C2MAPTKDM4E
SCHEMBL3634308 0.72 FABP4 (0.39) GRIN1GRIN2BNPBWR1PTGS1PTGS2
SCHEMBL287302 0.72 AKR1C3 (0.41) NPBWR1AKR1C3AKR1C2MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024149676-A1 HERBICIDAL PYRAZOLE COMPOUNDS SYNGENTA CROP PROTECTION AG (CH) 2024-07-18 WO disclosed