Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 16/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497003 | 0.92 | CRHR1 (0.39) | CRHR1ALDH1A1HPGDKDM4E | |
| SCHEMBL2930712 | 0.91 | CRHR1 (0.39) | CRHR1HPGDKDM4EMAPTMEN1 | |
| SCHEMBL12409295 | 0.89 | CRHR1 (0.40) | CRHR1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2178265 | 0.88 | CRHR1 (0.39) | CRHR1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2933140 | 0.85 | CRHR1 (0.38) | CRHR1KDM4EMAPTPOLB | |
| SCHEMBL20756845 | 0.83 | CRHR1 (0.38) | CRHR1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL2494970 | 0.82 | CRHR1 (0.38) | CRHR1ALDH1A1HPGDKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL545948 | 0.81 | CRHR1 (0.40) | CRHR1HPGDPOLB | |
| SCHEMBL20756306 | 0.81 | CRHR1 (0.39) | CRHR1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL25490375 | 0.81 | CRHR1 (0.49) | CRHR1ALDH1A1HPGDKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |