Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930712 | 0.87 | CRHR1 (0.39) | CRHR1KDM4EPOLBMAPT | |
| SCHEMBL2498882 | 0.87 | POLB (0.39) | CRHR1KDM4EPOLBCYP1A2GRM8 | |
| SCHEMBL2495462 | 0.86 | KDM4E (0.38) | CRHR1KDM4EPOLBCYP1A2GRM8 | |
| SCHEMBL2932988 | 0.85 | CRHR1 (0.38) | CRHR1KDM4EPOLBMAPT | |
| SCHEMBL2929183 | 0.83 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL2495432 | 0.82 | POLB (0.40) | CRHR1KDM4EPOLBCYP1A2GRM8 | |
| SCHEMBL2500602 | 0.82 | CRHR1 (0.32) | CRHR1CYP1A2GRM8GRM7 | |
| SCHEMBL2493432 | 0.82 | CYP1A2 (0.37) | CRHR1KDM4EPOLBCYP1A2GRM8 | |
| Hydrochloric Acid SCHEMBL545948 | 0.80 | CRHR1 (0.40) | CRHR1POLB | |
| SCHEMBL2931328 | 0.80 | PIK3CG (0.38) | KDM4EPOLBCYP1A2GRM8GRM7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |