Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13850530 | 0.84 | KDM4E (0.47) | KDM4EGAAHPGDHSD17B10GRIN2D | |
| SCHEMBL12402395 | 0.73 | ALDH1A1 (0.37) | KDM4EGAAHPGDHSD17B10ALDH1A1 | |
| SCHEMBL29330288 | 0.71 | ALDH1A1 (0.38) | KDM4EGAAHPGDDAOALDH1A1 | |
| SCHEMBL21719469 | 0.70 | ALDH1A1 (0.34) | KDM4EALDH1A1SMN1; SMN2CA2POLB | |
| SCHEMBL23686003 | 0.68 | LMNA (0.38) | KDM4EALDH1A1PDE3BPDE3ACA2 | |
| SCHEMBL22674257 | 0.68 | HMBS (0.43) | KDM4EGAAHPGDGRIN2DGRIN3B | |
| SCHEMBL19779639 | 0.67 | DAO (0.60) | KDM4EGAAHPGDHSD17B10DAO | |
| SCHEMBL20193913 | 0.67 | DAO (0.60) | KDM4EGAAHPGDHSD17B10DAO | |
| SCHEMBL24061201 | 0.67 | DAO (0.52) | KDM4EHSD17B10DAOALDH1A1SMN1; SMN2 | |
| SCHEMBL837270 | 0.66 | BRD4 (0.59) | KDM4EHPGDHSD17B10GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12043613-B2 | Inhibitors of SARM1 | DISARM THERAPEUTICS, INC. (US) | 2024-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12043613-B2 | Inhibitors of SARM1 | SARM1, SMN1; SMN2, SARNP | KDM4E 3087/4885GAA 1897/4885HPGD 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.