Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | JAK1 | P23458 | 4/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932566 | 0.94 | CHEK1 (0.57) | CHEK1MAP3K7TNIKJAK1IKBKB | |
| SCHEMBL2932338 | 0.86 | CHEK1 (0.55) | CHEK1MAP3K7JAK1IKBKB | |
| SCHEMBL2930060 | 0.86 | CHEK1 (0.70) | CHEK1MAP3K7IKBKB | |
| SCHEMBL2932064 | 0.85 | CHEK1 (0.54) | CHEK1MAP3K7IKBKB | |
| SCHEMBL1927166 | 0.85 | CHEK1 (0.72) | CHEK1MAP3K7IKBKB | |
| SCHEMBL2933445 | 0.85 | CHEK1 (0.72) | CHEK1MAP3K7IKBKB | |
| SCHEMBL2933039 | 0.83 | CHEK1 (0.73) | CHEK1MAP3K7IKBKB | |
| SCHEMBL2934362 | 0.83 | CHEK1 (0.58) | CHEK1MAP3K7IKBKB | |
| SCHEMBL2926946 | 0.83 | KDM4E (0.53) | CHEK1 | |
| SCHEMBL2931228 | 0.83 | CHEK1 (0.51) | CHEK1MAP3K7JAK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |