SCHEMBL29333817

SCHEMBL29333817

C=C(C(=O)N1CCOC[C@H]1c1cc(Cl)cc(-c2ncnc(N)n2)c1)C(F)(F)F

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ CCNC P24863 1/20 0.34
▸ CDK8 P49336 1/20 0.34
▸ MAPK1 P28482 1/20 0.32
▸ BTK Q06187 1/20 0.31
▸ PIK3CA P42336 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30855042 1.00 CCNC (0.34) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL29333821 0.91 CCNC (0.36) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL30855231 0.91 CCNC (0.36) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL29333811 0.89 CCNC (0.36) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL30855085 0.89 CCNC (0.36) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL29333450 0.84 CCNC (0.34) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL29335758 0.84 CCNC (0.34) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL31008576 0.84 CCNC (0.34) CCNCCDK8MAPK1BTKPIK3CA
SCHEMBL30855074 0.83 MALT1 (0.37) CCNCCDK8PIK3CA
SCHEMBL29333889 0.83 MALT1 (0.37) CCNCCDK8PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240226114-A1 INHIBITORS AND USES THEREOF VIVIDION THERAPEUTICS, INC. 2024-07-11 — — US disclosed
US-20240226114-A1 INHIBITORS AND USES THEREOF VIVIDION THERAPEUTICS, INC. 2024-07-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240226114-A1 INHIBITORS AND USES THEREOF KEAP1, NQO1, NFE2L2 CCNC 4349/4885CDK8 1776/4885MAPK1 1406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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