SCHEMBL2933535

SCHEMBL2933535

C=Cc1cccc(CN2CCN(C)CC2)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CXCR4 P61073 2/20 0.45
MC4R P32245 1/20 0.44
KDM4E B2RXH2 2/20 0.42
HRH4 Q9H3N8 2/20 0.42
PRKCB P05771 1/20 0.41
LCK P06239 1/20 0.41
LYN P07948 1/20 0.41
SRC P12931 1/20 0.41
PRKCH P24723 1/20 0.41
PRKCE Q02156 1/20 0.41
PRKCQ Q04759 1/20 0.41
PRKCD Q05655 1/20 0.41
HDAC3 O15379 3/20 0.40
HDAC4 P56524 3/20 0.40
HDAC1 Q13547 3/20 0.40
HDAC7 Q8WUI4 3/20 0.40
HDAC2 Q92769 3/20 0.40
HDAC10 Q969S8 3/20 0.40
HDAC11 Q96DB2 3/20 0.40
HDAC8 Q9BY41 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30786130 0.86 CXCR4 (0.49) CXCR4KDM4EPRKCQPRKCDTDP1
SCHEMBL22205248 0.84 CXCR4 (0.61) CXCR4MC4RKDM4EHRH4LMNA
Hydrochloric Acid SCHEMBL29604571 0.82 CXCR4 (0.59) CXCR4MC4RKDM4EHRH4LMNA
Bromide SCHEMBL29604007 0.82 CXCR4 (0.59) CXCR4MC4RKDM4EHRH4LMNA
SCHEMBL2930377 0.82 HRH3 (0.47) CXCR4KDM4ELMNA
SCHEMBL14851189 0.78 HTR3E (0.53) CXCR4MC4RKDM4EHRH4LMNA
SCHEMBL24915183 0.76 CXCR4 (0.53) CXCR4MC4RKDM4EHRH4LMNA
SCHEMBL30323744 0.76 CXCR4 (0.49) CXCR4MC4RKDM4EHRH4LMNA
SCHEMBL5253618 0.76 FAAH (0.54) CXCR4MC4RKDM4EHRH4TDP1
SCHEMBL17331651 0.76 HTR3E (0.54) CXCR4MC4RKDM4EHRH4LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2229377-A1 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS Wyeth LLC (US) 2010-09-22 EP disclosed
WO-2009076602-A1 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS WYETH (US) 2009-06-18 WO disclosed