Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TACR2 | P21452 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29337125 | 0.76 | CYP2D6 (0.51) | CYP2D6ALDH1A1GAAHTR6KMT2A | |
| SCHEMBL27249941 | 0.76 | LMNA (0.47) | ALDH1A1L3MBTL1GAAKDM4ELMNA | |
| SCHEMBL29336734 | 0.75 | CYP2D6 (0.48) | CYP2D6ALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL29336975 | 0.72 | ALDH1A1 (0.44) | CYP2D6ALDH1A1GAAKDM4ELMNA | |
| SCHEMBL29337104 | 0.71 | ALDH1A1 (0.42) | ALDH1A1L3MBTL1GAAKDM4ELMNA | |
| SCHEMBL1856027 | 0.69 | BCHE (0.79) | CYP2D6ALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL29336695 | 0.68 | OPRK1 (0.47) | CYP2D6ALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL29992486 | 0.67 | HTR2A (0.76) | CYP2D6HRH3HTR6TACR2 | |
| SCHEMBL29338313 | 0.67 | ALDH1A1 (0.40) | CYP2D6ALDH1A1L3MBTL1GAAKDM4E | |
| SCHEMBL734052 | 0.67 | HTR2A (0.76) | CYP2D6HRH3HTR6TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | CYP2D6 658/4885ALDH1A1 1786/4885L3MBTL1 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.