Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15884247 | 0.98 | L3MBTL1 (0.54) | L3MBTL1ATMKDM4EMEN1ALDH1A1 | |
| SCHEMBL2933385 | 0.93 | CHRNB2 (0.56) | L3MBTL1ATMKDM4EMEN1ALDH1A1 | |
| SCHEMBL2935953 | 0.91 | CHRNB2 (0.57) | L3MBTL1ATMKDM4EHRH3CHRNB2 | |
| SCHEMBL15884439 | 0.86 | HRH3 (0.54) | KDM4EALDH1A1HRH3KCNH2 | |
| SCHEMBL15884438 | 0.81 | HRH3 (0.50) | L3MBTL1KDM4EHRH3CHRNB2CHRNA4 | |
| SCHEMBL27995047 | 0.80 | HRH3 (0.60) | L3MBTL1ATMHRH3CHRNB2CHRNA4 | |
| SCHEMBL2936683 | 0.79 | CHRNB2 (0.51) | KDM4EMEN1ALDH1A1KMT2AHRH3 | |
| SCHEMBL19668758 | 0.79 | CHRNB2 (0.46) | CHRNB2CHRNA4 | |
| SCHEMBL3577214 | 0.78 | TSHR (0.55) | KDM4EALDH1A1CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL7669872 | 0.77 | CHRNB2 (0.51) | L3MBTL1CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |